Hidden three-state survival model for bivariate longitudinal count data

摘要

A model is presented that describes bivariate longitudinal count data by conditioning on a progressive illness-death process where the two living states are latent. The illness-death process is modelled in continuous time, and the count data are described by a bivariate extension of the binomial distribution. The bivariate distributions for the count data approach include the correlation between two responses even after conditioning on the state. An illustrative data analysis is discussed, where the bivariate data consist of scores on two cognitive tests, and the latent states represent two stages of underlying cognitive function. By including a death state, possible association between cognitive function and the risk of death is accounted for.