Preparation of Unsintering Calcium Phosphate Macroporous Materials with Hydroxyapatite Nanowhisker In-Situ Growth

摘要

Unsintering macroporous calcium phosphate scaffolds with macropore sizes of 200～400μm and hydroxyapatite nanofiber of in-situ growth were prepared by coating porous polyurethane templates with α-tricalcium phosphate bone cement (CPC) slurry, and their subsequent hydrolysis to calcium deficient hydroxyapatite (HAp) during the self-setting processes are presented. The effects of Sr~(2+) (SrNO_3) on the nucleation, growth of the hydroxyapatite nanofiber and phase constitution were studied. The results show that the main component of the coating is HA after hydrolysis for 72h and the Sr~(2+) added could depress the growth of block or sheet HA crystal and promote the nanowhisker growth. This new processing technique can be used to improve the bioactivity of porous polymer template while maintaining its macroporous structure.