SEQUENCE-CONTROLLED REGIOSELECTIVE SYNTHESIS OF POLYESTERS

摘要

The ability to precisely control polymer size and sequence is essential for tuning polymer properties and developing new functional materials. Among the synthetic biomaterials that have gained significant interest for its utility in applications such as targeted drug delivery and bioabsorbable structures is poly(lactic-co-glycolic acid) (PLGA). Underlying PLGA's utility is the ability to undergo nontoxic hydrolytic degradation in vivo, with tunable degradation rates, among other desirable properties. But the conventional synthesis of PLGA produces a random copolymer with little control over monomer sequence.