Catalytic Ring-Closing Metathesis of Dienes: Application to the Synthesis of Eight-Membered Rings

摘要

This paper has presented our results concerning the application of complex 1 to the RCM reaction to prepare eight-membered rings. Unlike the application of 1 to the RCM of smaller rings, the present study reveals that eight-membered rings are more demanding in terms of both the amount of catalyst employed and the reaction conditions necessary to obtain good results (concentration, reaction time, temperature). However, we have found that a number of eight-memberedring substrate classes are amenable to synthesis in reasonable yield by RCM. Defining the parameters which influence the cyclization reaction and extending this reaction to systems of bioorganic importance are among our current objectives.