Total Synthesis of (+-)-Jiadifenin, a Non-peptidyl Neurotrophic Modulator

摘要

Fukuyama and colleagues recently reported the isolation of the majucin cage-like sesquiterpene jiadifenin (1) as an inseparable anomeric mixture in 0.001% yield from the methanol extract of the pericarps of Illicium jiadifengpi. (2S)-Hydroxy-3,4-dehydro-neomanjucin (2), also obtained from I. jiadifengpi, is a potential biosynthetic precursor of 1. Indeed, Fukuyama and co-workers demonstrated that 2 could be converted by chemical means to jiadifenin (1) through the intermediacy of ketones 3 and 4, themselves isolated from Illicium majus (Scheme 1).