Total Synthesis of (±)-Perophoramidine

摘要

Perophoramidine and communesin B are two architecturally intriguing natural products related by their presumed biosynthetic origin from two molecules of tryptamine. Their structural differences are substantial, however, since perophoramidine (1) embodies a bis-amidine rather than the bis-aminal functionality present in communesin B, (2) lacks the azepine ring system of communesin B, (3) possesses a trans- rather than cis-stereochemical relationship of the vicinal quaternary centers, and (4) contains halogenated aromatic rings.