High-Resolution NMR Spectra in Inhomogeneous Fields via IDEAL (Intermolecular Dipolar-Interaction Enhanced All Lines) Method

摘要

High-resolution NMR is a powerful tool for analyzing molecular structures and dynamics. There are many circumstances where the spatial homogeneity of the magnetic fields is degraded, for instance, by magnetic susceptibilities of various tissues in biomedical in vivo spectroscopy, with ex situ analysis of rock samples for oil exploration, or in studies of porous resin beads in combinatorial chemistry. Distributions of inhomogeneous magnetic field and susceptibility produce spurious field gradients that broaden peaks. In this communication we report a new NMR detection scheme which we call IDEAL (intermolecular dipolar-interaction enhanced all lines) method, which can produce high-resolution NMR spectra in inhomogeneous fields, while maintaining quantitative relationships of chemical shifts, J coupling constants, multiplicity patterns, and relative peak areas.