Magnetically Recoverable Chiral Catalysts Immobilized on Magnetite Nanoparticles for Asymmetric Hydrogenation of Aromatic Ketones

摘要

We have designed novel magnetite nanoparticle-supported chiral Ru complexes that catalyze heterogeneous asymmetric hydrogenation of aromatic ketones with remarkably high activity and enantioselectivity. The heterogenized catalysts can be readily recycled by magnetic decantation and used for asymmetric hydrogenation for up to 14 times without loss of activity and enantioselectivity. Orthogonal nature of the present catalyst immobilization approach should allow the design of other superpara-magnetic nanoparticle-supported asymmetric catalysts for a wide range of organic transformations.