Iso-Migrastatin Congeners from Streptomyces platensis and Generation of a Glutarimide Polyketide Library Featuring the Dorrigocin,Lactimidomycin,Migrastatin,and NK30424 Scaffolds

摘要

Migrastatin(1)is a tumor cell migration specific inhibitor,and synthetic analogues of 1 have been prepared as therapeutic candidates for treating tumor metastasis.Dorrigocins A(2)and B(3)are novel natural product inhibitors of carboxyl methyltrans-ferase involved in the processing of Ras-related proteins,serving as a valuable tool to study cellular signal transduction.Structurally related to 1,2,and 3 are lactimidomycin(4)and NK30424 A(5)and B(6).