Copper(Ⅱ) Acetate Promoted Intramolecular Diamination of Unactivated Olefins

摘要

Nitrogen heterocycles containing the vicinal diamine unit are ubiquitous in biologically active small molecules and are also common ligands for inorganic as well as organic catalysts. An intramolecular alkene diamination offers a direct method for the synthesis of cyclic vicinal diamines. Herein is presented the first intramolecular diamination of unactivated olefins. This method is general for the formation of both five- and six-membered heterocycles, and substrate-based asymmetric induction has been achieved.