Synthesis of Nitric Oxide-Releasing Gold Nanoparticles

摘要

The astounding pace of discovery on the bioregulatory roles of nitric oxide (NO) demands new methods for generating NO in a controlled manner to facilitate both an improved understanding of NO's function in physiology and the development of NO-associated therapies.N-Diazeniumdiolate NO donors,small molecules synthesized by the reaction of amines with NO at elevated pressure,have proven particularly useful for spontaneously generating NO in aqueous solution.Indeed,the rate of NO generation is easily tuned by varying the amine precursor structure,pH,and/or temperature.