'Volatilizable' Supports for High-Throughput Organic Synthesis

摘要

Solid-phase synthetic approaches,pioneered by Bruce Merrifield in 1963,in conjunction with combinatorial methods developed over the past 20 years are highly efficient means for the production of tens of thousands of individual compounds and/or mixture-based libraries made up of millions of compounds.In conjunction with high-throughput biological screening,combinatorial approaches are now routinely used in the search for new pharmaceutical lead compounds.All currently utilized solid-phase organic synthetic supports require that the desired synthetic compound(s),whether they are low-molecular weight acyclic or heterocyclic compounds,peptidomimetics,peptides,or oligonucleotides,etc.,must be cleaved from the support and,as a final step,separated from the spent support.