Direct Observation of the Oxidative Addition of the Aryl Carbon-Oxygen Bond to a Ruthenium Complex and Consideration of the Relative Reactivity between Aryl Carbon-Oxygen and Aryl Carbon-Hydrogen Bonds

摘要

The transition-metal-catalyzed functionalization of unreactive aryl carbon-oxygen bonds in aryl ethers as well as that of unreactive carbon-hydrogen bonds is a potentially useful synthetic tool.Two types of catalytic reactions have been reported to date; one is the nickel-catalyzed coupling reaction of anisoles with Grignard reagents,and the other is the ruthenium-catalyzed coupling of ortho-alkoxy aromatic ketones with organoboronates.