Direct Boronation of Allyl Alcohols with Diboronic Acid Using Palladium Pincer-Complex Catalysis.A Remarkably Facile Allylic Displacement of the Hydroxy Group under Mild Reaction Conditions

摘要

Allyl alcohols are one of the most readily available substrates in palladium-catalyzed allylic displacement reactions.Unfortunately,the hydroxy group is one of the most reluctant leaving groups in substitution reactions,and therefore,application of harsh reaction conditions and employment of Lewis acids or other additives are required in these processes.However,employment of these reaction conditions and reagents precludes the efficient synthesis of unstable allyl metal derivatives,such as allyl boronates,in high isolated yields.