Reactivity of Pd(II) Complexes with Electrophilic Chlorinating Reagents: Isolation of Pd(IV) Products and Observation of C-CI Bond-Forming Reductive Elimination

摘要

The selective halogenation of aromatic molecules is an important organic transformation, as aryl halides serve as key components of or precursors to a wide variety of natural products, Pharmaceuticals, agrochemicals, and materials.12 We recently reported that Pd catalysts in conjunction with electrophilic halogenating reagents [particularly iodobenzene dichloride (PhICl_2) and A'-halosuccinim-ides (NXS, X = Cl, Br, I)] promote the ligand-directed conversion of arene C—H bonds into carbon—halogen bonds.