Regio- and Chemoselective Silylmetalation of Functionalized Terminal Alkenes

摘要

We have developed a new method for the chemoselective silylmetalation reaction of functionalized terminalrnalkenes, utilizing a catalyst system comprising catalytic Cu salt and a dianion-type Zn(Ⅱ) ate complex (SiBNOL-Zn-ate). The method provides a simple and direct route for the regio-controlled synthesis of a-substituted alkylsilanes and alcohols from various terminal alkenes. Efforts to expand the scope of the reaction and to elucidate the reaction pathway with the help of theoretical and spectroscopic studies are in progress in our laboratory.