Diastereoselective Nickel-Catalyzed Reductive Aldol Cyclizations Using Diethylzinc as the Stoichiometric Reductant: Scope and Mechanistic Insight

摘要

In the presence of diethylzinc as a stoichiometric reductant, Ni(acac)_2 functions as an efficient precatalyst for the reductive aldol cyclization of α,β-unsaturated carbonyl compounds tethered to a ketone electrophile through an amide or an ester linkage