Oxidatively Intercepting Heck Intermediates: Pd-Catalyzed 1,2- and 1,1-Arylhalogenation of Alkenes

摘要

Palladium-catalyzed cascade reactions are widely used for the assembly of complex organic molecules. These transformations frequently involve cr-alkyl Pd intermediates that are formed by Heck-type olefin insertion into a Pd-aryl bond (A in eq 1). Such intermediates are typically intercepted by olefin/alkyne insertion or CO insertion to afford valuable functionalized products. In contrast, selective and high yielding approaches to the direct oxidative functionalization of Heck intermediates remain rare.