Electrophoresis of Membrane-Associated Molecules in Packed Beds of Bilayer-Coated Particles

摘要

Lipid bilayers in the liquid-crystalline phase are two-dimensional fluids which form the structural basis for all biological membranes. Electrophoresis in a fluid lipid bilayer is an ideal strategy for separation of membrane-associated biomolecules (e.g., lipids and membrane proteins) in their native environment, because it does not require their extraction from the membranes by solvents or detergents in contrast to conventional methods using chromatog-raphy or gel electrophoresis.