Oligocarbonate Molecular Transporters: Oligomerization-Based Syntheses and Cell-Penetrating Studies

摘要

New strategies, devices, and agents that enable or enhance the passage of drugs or probes across biological barriers are required to address a range of major challenges in chemotherapy, imaging, diagnostics, and mechanistic chemical biology. In 2000, we reported that the cellular uptake of the Tat_(49-57) peptide could be mimicked by homooligomers of arginine. Uptake was shown to be a function of the number and array of guanidinium groups, observations that led to the design and synthesis of the first guanidinium-rich (GR) peptoids, GR-spaced peptides, GR-oli-gocarbamates and GR-dendrimeric molecular transporters (MoTrs).