Palladium-Catalyzed Direct Carboxylation of Aryl Bromides with Carbon Dioxide

摘要

Because of its abundance, low cost, nontoxicity and high potential as a renewable source, carbon dioxide (CO_2) has recently gained considerable momentum as the ideal Cl source.As a result, CO_2 fixation has become an active area of research in both academic and pharmaceutical laboratories.rnBenzoic acids are important motifs found in many natural and medicinally important compounds.In recent years, metal-catalyzed carbonylation of aryl halides (Scheme 1, route a) and carboxylation of carbon nucleophiles with CO_2 (Scheme 1, route b) have become powerful alternatives to the classical synthetic approaches for these compounds.