Total Synthesis of Chloropeptin II (Complestatin) and Chloropeptin I

摘要

Complestatin (1, chloropeptin II) was first disclosed in 1980 as an inhibitor of the alternate pathway of human complement,Figure 1. Nine years later, both its original isolation from Streptomyces lavendulae at Sankyo and additional details of its complement activity were reported along with its structure elucidation by Seto that defined its connectivity and partial stereochemistry. Shortly thereafter, the first report of its activity against HIV infectivity and its cytopathic effects were disclosed.