Enantioselective α-Trifluoromethylation of Aldehydes via Photoredox Organocatalysis

摘要

Organofiuorine compounds possess unique physical properties that are exploited in a wide range of applications such as dyes, polymers, agrochemicals, and pharmaceuticals. In medicinal chemistry, for example, valuable physiological properties are often conferred on "drug-like" molecules via the incorporation of CF_3 groups that enhance binding selectivity, elevate lipophilicity, and/ or improve metabolic stability.