Bifunctional Acyltransferase/Decarboxylase LnmK as the Missing Link for β-Alkylation in Polyketide Biosynthesis

摘要

Both a- and β-alkylations contribute to the vast structural diversity displayed by polyketide natural products (Figure 1A). While the a-alkyl branches are typically derived from extender units, the choice of which is dictated by the acyltransferase (AT) domain of modular polyketide synthases (PKSs), the β-alkyl branches often result from the activities of hydroxymethylglutaryl-CoA (HMG-CoA) synthase homologues (HCSs).