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Well-Defined DNA Nanoparticles Templated by Self-Assembled M_(12)L_(24) Molecular Spheres and Binding of Complementary Oligonucleotides

机译:自定义的M_(12)L_(24)分子球和互补寡核苷酸的结合模板的定义良好的DNA纳米粒子。

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摘要

Perfectly monodisperse DNA nanoparticles were prepared via the self-assembly of 12 Pd(Ⅱ) ions and 24 bidentate ligands functionalized with oligonucleotides of varying length (n = 1 -3). The DNA nanoparticles formed hydrogen bonds with cDNA strands and an insoluble aggregate formed only with matching trimeric nucleotide strands (tri-A).
机译:通过12个Pd(Ⅱ)离子和24个双齿配体的自组装,制备了完美的单分散DNA纳米粒子,这些配体被不同长度的寡核苷酸官能化(n = 1 -3)。 DNA纳米颗粒与cDNA链形成氢键,不溶性聚集体仅与匹配的三聚核苷酸链(tri-A)形成。

著录项

  • 来源
    《Journal of the American Chemical Society》 |2010年第45期|p.15930-15932|共3页
  • 作者单位

    Department of Applied Chemistry, School of Engineering, The University of Tokyo, and JST-CREST, 7-3-1 Hongo, Bunk yo-ku, Tokyo 113-8656, Japan;

    Department of Applied Chemistry, School of Engineering, The University of Tokyo, and JST-CREST, 7-3-1 Hongo, Bunk yo-ku, Tokyo 113-8656, Japan;

    Department of Applied Chemistry, School of Engineering, The University of Tokyo, and JST-CREST, 7-3-1 Hongo, Bunk yo-ku, Tokyo 113-8656, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 入库时间 2022-08-18 03:15:56

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