Direct C-H Arylation of Electron-Deficient Heterocycles with Arylboronic Acids

摘要

A direct arylation of a variety of electron-deficient het erocycles with arylboronic acids has been developed. This new reaction proceeds readily at room temperature using inexpensive reagents: catalytic silver(Ⅰ) nitrate in the presence of persulfate co oxidant. The scope with respect to heterocycle and boronic acid coupling partner is broad, and sensitive functional groups are tolerated. This method allows for rapid access to a variety of arylated heterocycles that would be more difficult to access with traditional methods.