Enantioselective Synthesis of (E)-δ-Stannyl Homoallylic Alcohols via Aldehyde Allylboration Using α-Stannylallylboranes Generated by Allene Hydroboration Followed by a Highly Diastereoselective 1,3-Boratropic Shift

摘要

The asymmetric carbonyl allylation reaction is an important transformation in organic synthesis. Although extensive efforts over the past three decades have provided many useful allylmetal reagents, new developments in this area continue to emerge. One disadvantage of the vast majority of prior allylation methods, however, is that homoallylic alcohols with terminal vinyl groups are generated.