Identification of Protein-Bound Dinitrosyl Iron Complexes by Nuclear Resonance Vibrational Spectroscopy

摘要

Among various sites of nitric oxide reactivity in biology, iron-sulfur clusters have emerged as an important class of metallocofactors targeted by NO. Proteins containing these clusters perform a diverse array of functions from electron transfer to small molecule sensing and substrate binding. Consequently, iron-sulfur clusters are potential sites for both NO-derived physiological signal transduction and toxicity.