Stereospecific Synthesis of Cyclobutylboronates through Copper(I)-Catalyzed Reaction of Homoallylic Sulfonates and a Diboron Derivative

摘要

Cyclobutanes have received considerable attention as prevalent structures in natural products and as versatile synthetic intermediates. However, synthetic methods for cyclobutanes with multiple stereocenters are relatively less developed than those for other ring systems. [2 + 2] Photocycloadditions are the most widely used and reliable method for stereoselective cyclobutane synthesis; however, high regio- and stereoselectivity is almost limited to the enone-alkene reactions.