Iridium(III)-Catalyzed Enantioselective Si-H Bond Insertion and Formation of an Enantioenriched Silicon Center

摘要

Recently, synthetic application of the compounds possessing silyl group(s) has been rapidly increasing, and the development of their efficient synthesis is a topic of interest. Although various methods are available for the preparation of silyl compounds, asymmetric Si-H functionalization is a direct method for the preparation of chiral compounds possessing silyl group(s). In particular, asymmetric Si-H insertion of a metal carbenoid derived from a-dia-zocarbonyl compounds is a potentially attractive route to produce chiral a-silylcarbonyl compounds.