Control of Olefin Geometry in Macrocyclic Ring-Closing Metathesis Using a Removable Silyl Group

Yikai Wang; Miguel Jimenez; Anders S. Hansen; Eun-Ang Raiber; Stuart L. Schreiber; Damian W. Young

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Control of Olefin Geometry in Macrocyclic Ring-Closing Metathesis Using a Removable Silyl Group

机译：使用可移动的硅烷基团控制大环封闭复分解中的烯烃几何形状

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Introducing a silyl group at one of the internal olefin positions in diolefinic substrates results in E-selective olefin formation in macrocyclic ring-forming metathesis. The application of this method to a range of macrocyclic (E)-alkenylsiloxanes is described. Protodesily-lation of alkenylsiloxane products yields novel Z-configured macrocycles.

机译：在二烯烃底物的内部烯烃位置之一处引入甲硅烷基基团导致在大环形成复分解中形成E-选择性烯烃。描述了该方法在一系列大环（E）-烯基硅氧烷中的应用。链烯基硅氧烷产物的原型化产生新的Z构型大环。

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《Journal of the American Chemical Society》 |2011年第24期|p.9196-9199|共4页
作者
Yikai Wang; Miguel Jimenez; Anders S. Hansen; Eun-Ang Raiber; Stuart L. Schreiber; Damian W. Young;
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作者单位

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States;

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States;

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States;

Chemical Biology Program, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States;

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States,Chemical Biology Program, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States;

Chemical Biology Program, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States;

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入库时间 2022-08-18 03:14:18

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1. New cyclic and macrocyclic silaolefins via ring-closing metathesis of 1,1-bis(silyl)ethene-tethered dienes [J] . Hreczycho G, Pawluc P, Kubicki M, Journal of Organometallic Chemistry . 2007,第12期

机译：通过1，1-双（甲硅烷基）乙烯系链的二烯的闭环复分解反应生成新的环状和大环硅烯烃
2. Selectivity in Olefin-Intervened Macrocyclic Ring-Closing Metathesis [J] . Liu Ruzhang, Ge Hua, Chen Kuanwei, ACS catalysis . 2018,第6期

机译：烯烃的选择性干预宏环闭闭复位
3. Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis [J] . Andersson H., Demaegdt H., Johnsson A., Journal of Medicinal Chemistry . 2011,第11期

机译：封闭环易位的胰岛素调节性氨基肽酶（IRAP）的强大环抑制剂
4. A Synthetic Approach to Aromatic Compounds Using Ring-Closing Olefin Metathesis and Ring-Closing Enyne Metathesis [C] . Hidetoshi Takahashi, Kazuhiro Yoshida, Tsuneo Imamoto Symposium on Organometallic Chemistry . 2008

机译：芳香族化合物的合成方法使用环闭烯烃复分解和闭环enyne复分解
5. Studies on Application of Silyl Groups in Ring-Closing Metathesis Reactions and Fragment-Based Probe Discovery [D] . Wang, Yikai 2012

机译：甲硅烷基在封闭环复分解反应和基于片段的探针发现中的应用研究
6. Control of Olefin Geometry in Macrocyclic Ring-Closing Metathesis Using a Removable Silyl Group [O] . Yikai Wang, Miguel Jimenez, Anders S. Hansen, -1

机译：使用可移动性硅基的烯烃几何控制在大环闭环易位
7. Control of Olefin Geometry in Macrocyclic Ring-Closing Metathesis Using a Removable Silyl Group [O] . Yikai Wang, Miguel Jimenez, Anders S. Hansen, 2011

机译：使用可移除的甲硅烷基团控制甲烯烃几何学中的甲基闭合复分解
8. Ring-Closing Metathesis of Macrocyclic Compounds and Cross-Metathesis of Allyl Esters of Amino Acids Leading to Peptidominetics [R] . Low, T. K. , Enholm, E. 2005

机译：大环化合物的闭环复分解和氨基酸烯丙基酯的交叉复分解导致肽动力学

Control of Olefin Geometry in Macrocyclic Ring-Closing Metathesis Using a Removable Silyl Group

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