Copper-Catalyzed Enantioselective Intramolecular Alkene Amination/lntermolecular Heck-Type Coupling Cascade

摘要

Enantioselective copper-catalyzed cycliza-tion of γ-alkenylsulfonamides and a δ-alkenylsulfonamide in the presence of a range of vinyl arenes results in variously functionalized 2-substituted chiral nitrogen heterocycles via a formal alkene C-H functionalization process. Application of this reaction to the concise synthesis of a 5-HT_7 receptor antagonist is demonstrated.