CYCLOADDITION MECHANISM VARIES BY CATALYST

摘要

Xin Hong, Barry M. Trost, and Ken Houk clarify the mechanistic details of a ruthenium-catalyzed cycloaddition and ene reaction using density functional theory As seven-membered rings are found in many natural products and drugs, such as the popular antihistamine desloratadine, chemists have sought to develop efficient ways to synthesize them. Though this task still presents a challenge, great strides have been made by using transition metals to catalyze cydoaddition reactions.