Networking Nanoswitches for ON/OFF Control of Catalysis

摘要

The nanoswitches 1 and 2 are interdepend-ently linked in so-called network states (NetStates). In NetState I, defined by presence of [Cu(1)]~+ and 2, the organocatalyst N-methylpyrrolidine catalyzes a conjugate addition. Addition of iron(II) ions as an external chemical trigger to NetState I discharges Cu~+ from [Cu(1)]~+. The liberated copper(I) ion acts as a second messenger and changes the toggling state at nanoswitch 2. The resulting nanoswitch [Cu(2)]~+ captures the catalytically active species from solution and the conjugate addition is turned OFF. Removal of the original trigger reverses the sequence and turns catalysis ON. The ON/OFF catalytic cycle was run three times in situ.