• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the American Chemical Society >Highly Enantioselective Hydrogenation of Amides via Dynamic Kinetic Resolution Under Low Pressure and Room Temperature
【24h】

Highly Enantioselective Hydrogenation of Amides via Dynamic Kinetic Resolution Under Low Pressure and Room Temperature

机译：在低压和室温下通过动态动力学拆分对酰胺进行高度对映选择性加氢

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

High-throughput screening and lab-scale opti-mization were combined to develop the catalytic system trans-RuCl_2((S,S)-skewphos)((R,R)-dpen), 2-PrONa, and 2-PrOH. This system hydrogenates functionalized α-phenoxy and related amides at room temperature under 4 atm H_2 pressure to give chiral alcohols with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution.
机译：高通量筛选和实验室规模的优化相结合，以开发反式RuCl_2（（S，S）-skewphos）（（R，R）-dpen），2-PrONa和2-PrOH的催化体系。该体系在室温下在4个atm H_2压力下氢化官能化的α-苯氧基和相关的酰胺，通过动态动力学拆分可得到最高99％的收率和超过99％的对映体过量的手性醇。

著录项

  • 来源
    《Journal of the American Chemical Society》 |2017年第8期|3065-3071|共7页
  • 作者

    Loorthuraja Rasu; Jeremy M. John; Elanna Stephenson; Riley Endean; Suneth Kalapugama; Roxanne Clément; Steven H. Bergens;

  • 作者单位

    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada;

    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada;

    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada;

    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada;

    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada;

    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada;

    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-18 03:07:55

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号