Preparation, Characterization and Controlled Release Investigation of Biocompatible pH-Sensitive PVA/PAA Hydrogels

摘要

In the present research hydrogel films based on polyvinyl alcohol (PVA) and polyacrylic acid (PAA) blend, with various crosslink densities, have been prepared through different thermal treatment. The results of FTIR and DSC confirmed quality and quantity of conclusion on miscibility of PVA/PAA blends, respectively. Besides, biocompatibility of the samples has been proved in cytotoxicity tests using L929 cells, according to ISO10993–5. Water uptake of the hydrogel blends is measured. pH sensitivity properties of blends are studied with and without boiling in NaOH solutions where the effect of swelling in water before boiling has also been investigated. Preswellings in water and NaOH concentration have been found to be mainly effective on pH sensitivity of PVA/PAA blends. Biocompatibility and pH sensitivity behavior make these hydrogels appropriate candidates to orally deliver drugs such as insulin and peptides that can be released in basic pH of intestine. The stability of these films in acidic solutions and its expansion and also the consequent release of drugs in basic solutions have been studied by using Teofilin as a model drug by UV-spectrophotometeric measurements.