NMR Structural Studies on Alamethicin Dimers

摘要

~(15)N labeled alamethicin dimer was synthesized. The structure and dynamics of alamethicin dimers were studied with nuclear magnetic resonance (NMR) spectroscopy. The data from ~(15)N-labeled alamethicin dimer suggest little differences in conformation between the dimer and monomer in the Aib_1-Pro_(14) region. Significant difference in the conformation of the C-terminus are manifest in the NH chemical shifts in the Val_(15) -Pho_(20) region.