Cell Adhesion Inhibition by RGD Peptides Linked with a Photoisomerizable Nonnatural Amino Acid

摘要

RGD peptides linked with a nonnatural amino acid, phenylazophenyl alaninine (azoAla), were synthesized and applied to cell adhesion inhibitors. The RGD peptides linked with azoAla at C-terminal showed potent binding to the integrin on the surface of HeLa cells. Photoisomerization effect of the azobenzene side chain of synthesized peptides on the ell adhesion inhibition was further investigated. It was demonstrated that the cis-form of azoAla-linked RGD peptides revealed a little weak cell adhesion inhibition effect as compared with trans-form of azoAla-linked RGD peptide.