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首页> 外文期刊>Journal of the Society for Information Display >Quantum dot light emitting devices for photomedical applications
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Quantum dot light emitting devices for photomedical applications

机译:用于光医学应用的量子点发光器件

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摘要

While OLEDs have struggled to find a niche lighting application that can fully take advantage of their unique form factors as thin, flexible, lightweight and uniformly large-area luminaire, photomedical researchers have been in search of low-cost, effective illumination devices with such form factors that could facilitate widespread clinical applications of photodynamic therapy (PDT) or photobiomodulation (PBM). Although existing OLEDs with either fluorescent or phosphorescent emitters cannot achieve the required high power density at the right wavelength windows for photomedicine, the recently developed ultrabright and efficient deep red quantum dot light emitting devices (QLEDs) can nicely fit into this niche. Here, we report for the first time the in-vitro study to demonstrate that this QLED-based photomedical approach could increase cell metabolism over control systems for PBM and kill cancerous cells efficiently for PDT. The perspective of developing wavelength-specific, flexible QLEDs for two critical photomedical fields (wound repair and cancer treatment) will be presented with their potential impacts summarized. The work promises to generate flexible QLED-based light sources that could enable the widespread use and clinical acceptance of photomedical strategies including PDT and PBM.
机译:尽管OLED一直在努力寻找可以充分利用其独特形状因数的薄型照明应用,例如薄,柔性,轻便且均匀的大面积照明器,但光医学研究人员一直在寻找具有这种形状的低成本,有效的照明设备可能促进光动力疗法(PDT)或光生物调节(PBM)广泛临床应用的因素。尽管现有的带有荧光或磷光发射器的OLED无法在光医学的正确波长窗口处实现所需的高功率密度,但最近开发的超高亮度,高效的深红色量子点发光器件(QLED)可以很好地适合这一领域。在这里,我们首次报告了一项体外研究,以证明这种基于QLED的光医学方法可以提高PBM控制系统的细胞代谢,并有效杀死PDT的癌细胞。将介绍为两个关键的光医学领域(伤口修复和癌症治疗)开发特定波长的柔性QLED的观点,并总结其潜在影响。这项工作有望产生基于QLED的灵活光源,该光源可以使包括PDT和PBM在内的光医学策略得到广泛使用和临床接受。

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  • 作者单位

    College of Optics and Photonics, University of Central Florida, Orlando, FL, USA,Nanoscience Technology Center, University of Central Florida, Orlando, FL, USA;

    College of Optics and Photonics, University of Central Florida, Orlando, FL, USA;

    Raymond J Lanzafame MD PLLC, Rochester, NY, USA,Laser Surgical Research Laboratory, Rochester General Hospital, Rochester, NY, USA;

    Laser Surgical Research Laboratory, Rochester General Hospital, Rochester, NY, USA;

    Department of Physics, University of Massachusetts Boston, Boston, MA, USA;

    Department of Physics, University of Massachusetts Boston, Boston, MA, USA;

    Department of Physics, University of Massachusetts Boston, Boston, MA, USA;

    Harvard Medical School, Wellman Center for Photomedicine, Boston, MA, USA;

    Harvard Medical School, Wellman Center for Photomedicine, Boston, MA, USA;

    Roswell Park Cancer Institute, Photodynamic Therapy Center, Buffalo, NY, USA;

    Roswell Park Cancer Institute, Photodynamic Therapy Center, Buffalo, NY, USA;

    ITRC AMOLED Research Center, Sungkyunkwan University, Korea;

    College of Optics and Photonics, University of Central Florida, Orlando, FL, USA;

    College of Optics and Photonics, University of Central Florida, Orlando, FL, USA,Nanoscience Technology Center, University of Central Florida, Orlando, FL, USA,Department of Materials Science and Engineering, University of Central Florida, Orlando, FL, USA;

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  • 正文语种 eng
  • 中图分类
  • 关键词

    quantum dot light emitting devices (QLEDs); photomedicine; photodynamic therapy; photobiomodulation;

    机译:量子点发光器件(QLED);光医学光动力疗法;光生物调节;

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