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Intracameral injection of platelet activating factor as a mediator of intraocular inflammation in rabbit eyes

机译:前房内注射血小板活化因子作为家兔眼内炎症的介质

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摘要

Objective To evaluate platelet activating factor (PAF) induced aqueous flare, corneal edema, pupillary constriction and biphasic intraocular pressure (IOP) changes in the rabbit eyes. Methods PAF was delivered into anterior chamber by intracameral injection, other antagonists were administered systemically. Results PAF induced responses in a dose-dependent manner. All of the responses to PAF were inhibited by the PAF receptor antagonist, BN 52021 (20mg/kg, i.p.).
机译:目的评价兔眼中血小板活化因子(PAF)引起的房水耀斑,角膜水肿,瞳孔缩小和双相眼压(IOP)的变化。方法通过前房内注射将PAF送入前房,全身应用其他拮抗剂。结果PAF以剂量依赖性方式诱导反应。 PAF受体拮抗剂BN 52021(20mg / kg,i.p.)抑制了所有对PAF的反应。

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