Synthesis, coordination and biological aspects of organotin(IV) derivatives of 4-[(2,4-dinitrophenyl)amino)]-4-oxo-2-butenoic acid and 2-{[(2,4-dinitrophenyl)amino]carbonyl}benzoic acid

摘要

New series of organotin(IV) complexes of aniline derivatives, R_2SnL_2 and R_3SnL [where R = Me, n-Bu, Ph, n-Oct] have been synthesized by the reaction of HL~1 and HL~2 with respective organotin halides or oxides. Experimental details for the preparation and characterization (including elemental analysis, IR and multinuclear NMR (~1H-, ~(13)C- and ~(119)Sn-) spectra in CDCl_3 and El mass spectra of both series are provided. The binding sites of the ligands were identified by means of FTIR spectroscopic measurements. It was found that in all cases the organotin(IV) moiety reacts with the oxygen of COO- group to form new complexes. In the diorganotin complexes, the COO- group is coordinated to the organotin(IV) centres in a bidentate manner in the solid state. The ~119Sn NMR data and the ~nJ(~(13)C-~(119/117)Sn) coupling constant support the tetrahedral coordination geometry of the organotin complexes in non-coordinating solvents. Biological activities (antibacterial, antifungal, cytotoxicity, an-tileishmanial and insecticidal) of these compounds are also reported.