Formulation and development of antipsoriatic herbal gelcream

摘要

This study presents formulation and development of patient friendly antipsoriatic topical gelcreams using Simulgel NS and Sepicide HB with Myrrh oil. Optimized formulation F5 depicted that gelcream had a viscoelastic nature with good creep recovery, and non-Newtonian behavior. Stability studies for three months at 40± 2℃ and 75±5% RH of Formulation F5 showed no change in colour and consistency, and pH remained between 5.7 and 5.9. Primary skin irritation test conducted on 30 healthy volunteers demonstrated nonirritating nature of F5. Thus Simulgel NS and Sepicide HB (cone, 2% w/v each) were found to give better anti-inflammatory gelcream containing myrrh oil with good consistency and stability.