In vitro release of L-arginine and cysteine from MCM-48: a study on effect of size of active biomolecules on release rate

摘要

The present paper consists of encapsulation of l-arginine as well as cysteine into MCM-48 with different amount and its characterization using various physicochemical techniques such as TEM, BET surface area, FT-IR, TGA, Powder XRD and Si-29 MAS NMR. The in-vitro release study of l-arginine as well as cysteine was carried out in simulated body fluid under static as well as stirring condition. A study on release kinetic as well as mechanism was also carried out using first ordered release kinetic model. The release profile of l-arginine and cysteine was co-related with the size and structure of biomolecules.