Isopinocampheylchloroborane: A Promising New Reagent for Asymmetric Cyclic Hydroboration. A Simple Procedure To Convert 1-Allyl-1-cyclohexene into trans-1-Decalone of ≥ 99% Optical Purity

摘要

In the past, boron annulation via cyclic hydroboration has been studied in considerable detail by our group. This reaction has emerged as an important synthetic tool in the synthesis of natural products. A general ste-reospecific synthesis of trans-fused bicyclic ketones of different classes has been reported via the cyclic hydroboration-carbonylation protocol of representative dienes with thexylborane (ThxBH_2) (eq 1).