Lobatamides a and b, novel cytotoxic macrolides from the tunicate aplidium lobatum

摘要

Over the last 25 years, tunicates have proven to be a consistent source of interesting and novel bioactive natural products. Indeed, the first biologically active tunicate metabolites were isolated from the genus Ap- lidium. Here, we report the isolation of two novel, cytotoxic macrolides, lobatamides A(1) and B (2), from the tunicate Aplifium lobatum.