Regioselective hydrometalation of alkenes reveals the amphipolar nature of the pd-H bond in heterogeneous hydrogenation

摘要

Catalytic hydrogenation using heterogeneous transi- tion-metal catalysts, such as palladium on cargon, is an important synthetic method widely used for the last 50 years, for example in the selective reduction of alkynes to cis-alkenes. Recently, there has been much interest in developing heterogeneous catalysts modified with chirl auxiliaries that can be used for asymmetric reduc- tion of prochiral alkenes and ketones.