Unsaturated nitriles: optimized coupling of the chloroprene grignard reagent with ω-bromonitriles

摘要

The Diels-Alder reaction is one of the most powerful reactions in organic synthesis. Efficient access to Diels- Alder precursors has stimulated several expedient diene Syntheses for both type I and type II Diels-Alder Reactions. A particularly efficient synthesis of dienes for Type II intramolecular Diels-Alder (IMDA) reactions Relies on coupling electrophiles with 1-methylene-2- Propenylmagnesinum chloride (2)~6-the so-called chloro- Prene Grignard reagent.