Tandem transformations involving allylic silanes. 2. Highly diastereoselective substitutions involving [(trialkylsilyl)methyl]cyclohexene derivatives with aldehydes. Synthetic studies on the problem of lewis acid-promoted Protodesilylation and enoliz

摘要

Diels-Alder cycloaddition of 2-[(trialkylsilyl)methyl]-1,3butadienes with a variety of dienophiles and substitution reactions between these allylsilane-containing adducts and aldehyde or acid chloride electrophiles have been combined into "tandem sequential reactions." These tandem sequences proceed with equal or greater yield (50-80/100) than the reactions performed separately with no decrease in regio- or stereoselectivity.