Efficient conversion of cephalomannine to paclitaxel and 3'-N-Acyl-3'-N-debenzoylpaclitaxel analogs

摘要

The clinically important anticancer drug paclitaxel (Taxol) (1) was, until recently, available only by a complex and expensive isolation process from Taxus breuifolia bark, which is a nonrenewable and relatively scarce resource. This dependence on bark as the source of a drug required in ever increasing amounts focused both public and scientific interest on the discovery of alternate sources, and several approaches to the produc- tion of paclitaxel have been investigated.