Synthesis and X-ray crystallographic structure of leucine-phenylalanyl succinimide-based pseudopeptides

摘要

The incorporation of a structural group, represented by X in Figure 1, which is known to inhibit a particular class of enzyme, into a peptide recognition sequence, has been the subject of much research. The aims of this work are to enhance the selectivity of an inhibitor toward a particular subclass of enzyme and also to produce fami- lids of peptide-based inhibitors to act as biological probes.